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1.
In short, it is the Craving or desire for the Unknown. Most widely believed to be innuendo for affection on a physical level, it can be also used to describe anything of a mysterious, unknown nature, that is craved...

A Breif History on the Origins:

A Message was sent Via SMS, stating that there was 5 points needed to get accross to the reciepient:
* The Recipient was loved
* The Recipient was missed
* The Recipient was wanted
* The Recipient was needed
* The *fifth point* would be expressed and/or demonstrated in person.

From that point in time on, the words 'Fifth Thing Syndrome' refered to the craving to have that fifth thing demonstrated. Thus, the 'Fifth Thing Syndrome' was born.

Its Basic Uses Summarised:
1) Sexual Innuendo
2) Mysterious Anticipation
3) Santie Claus
Use 1:
Boyfriend: Damn, you're looking fine tonight!
Girlfriend: I think you've got fifth thing Syndrome... I'm glad I'm not the only one!

Use 2:
Father: I think I got you a supprise
Son: Yes...? I want to see it, now!
Father: I think you have 'Fifth Thing Syndrome' No, I plan on saying these three words in conjunction to your want for a supprise to sound impressive

Use 3:
Louis Armstrong: 'Zat you, Santie Claus?
Santa: I have a present, but I'm going to hide it until the morning, so you build up anticpation, thus creating in yourself a Fifth Thing Syndrome
Beküldő: Big jasE 2005. február 11.